Glutamine

amino-acid · immune-hematologic · Oral · IV

Glutamine, an amino acid. Most abundant free AA in plasma and muscle. Primary fuel for enterocytes and lymphocytes (glutaminolysis). Nitrogen… Oral half-life 1 h.

Most abundant free AA in plasma and muscle. Primary fuel for enterocytes and lymphocytes (glutaminolysis). Nitrogen shuttle (amide group transfer). Precursor to GABA, glutathione (after hydrolysis to glutamate), and purine/pyrimidine biosynthesis. Conditionally essential in catabolic states (burns, trauma, critical illness).

Pharmacokinetics

• Oral — t½ 1 h · F 85%
• IV — t½ 1 h · F 100%

Sources: PMID:8974121, PMID:35032556