Goserelin

hormone · endocrine · reproductive · Subcutaneous

Goserelin, a hormone. Synthetic decapeptide GnRH/LHRH agonist. Continuous depot exposure first causes a transient… Subcutaneous half-life 4.2 h.

Synthetic decapeptide GnRH/LHRH agonist. Continuous depot exposure first causes a transient gonadotropin/sex-steroid surge ("flare"), then desensitizes pituitary GnRH receptors → castrate-level testosterone (men) or estradiol (women). Prostate/breast cancer, endometriosis.

Pharmacokinetics

• Subcutaneous — t½ 4.2 h · F 100% · Vd 15 L

Sources: PMID:10926349