Guanfacine

stimulant · nervous · Oral

Guanfacine, a stimulant. Selective α₂A-adrenergic agonist — prefrontal cortex postsynaptic α₂A activation enhances working memory + impulse… Oral half-life 17 h.

Selective α₂A-adrenergic agonist — prefrontal cortex postsynaptic α₂A activation enhances working memory + impulse control via cyclic-nucleotide gated channel modulation. Lower sedation than clonidine (less α2B activity).

ABSORPTION-RATE PROVENANCE: this value was derived by inverting the one-compartment peak-time relation in 2026-05-26-wave25-ka-from-tmax.ts, whose header claimed every peak time was verbatim from a primary human study. ALL FORTY-FOUR ENTRIES HAVE NOW BEEN CHECKED AND TWENTY-EIGHT FAIL. This one fails because the population is five patients with renal insufficiency plus five on chronic dialysis, and the figure is an upper bound, "within two hours". It is DISCLOSED RATHER THAN DELETED: a midpoint of a narrow range is usually inside the true spread, and removing it would fall back on the solver default of 1.0 per hour, which is worse for most of these records.

Pharmacokinetics

• Oral — t½ 17 h · F 80% · ka 1.98 h⁻¹ · Vd 420 L

Sources: PMID:6994775, PMID:1356570, PMID:7029332, PMID:3323255