Huperzine A

alkaloid · nervous · Oral

Huperzine A, an alkaloid. Reversible acetylcholinesterase inhibitor (Ki ~25 nM) — raises synaptic ACh. Higher CNS selectivity and longer duration… Oral half-life 12 h.

Reversible acetylcholinesterase inhibitor (Ki ~25 nM) — raises synaptic ACh. Higher CNS selectivity and longer duration than donepezil. Also NMDA receptor antagonist at higher concentrations (neuroprotective rationale). Used in China for Alzheimer's; Western supplement use for cognitive endpoints.

Pharmacokinetics

• Oral — t½ 12 h · F 97% · ka 4.549 h⁻¹ · Vd 140 L

Related compounds

• Alpha-GPC — synergistic

Sources: PMID:18348466