Hyaluronic Acid (systemic)

metabolite · integumentary · immune-hematologic · Transdermal · Intramuscular · Oral

Hyaluronic Acid (systemic), a metabolite. Linear GAG, major component of synovial fluid + ECM. Viscosupplementation theory (IA injection) + anti-inflammatory CD44…

Linear GAG, major component of synovial fluid + ECM. Viscosupplementation theory (IA injection) + anti-inflammatory CD44 signalling. PO oral bioavailability debated but multiple RCTs show modest knee-OA improvement at 80–200 mg/day over 8+ weeks. Dermal filler (crosslinked) separate product class.

Sources: PMID:7514978