Hydrochlorothiazide
Hydrochlorothiazide. Thiazide diuretic — inhibits Na+/Cl- cotransporter (NCC) in distal convoluted tubule of the kidney. First-line… Oral half-life 9.8 h.
Thiazide diuretic — inhibits Na+/Cl- cotransporter (NCC) in distal convoluted tubule of the kidney. First-line antihypertensive; mild Ca²⁺ retention reduces osteoporotic fractures vs loop diuretics. Hypokalemia + hyponatremia + hyperuricemia common.
PK: textbook real-PMID zero-content — none of the four stored values appears in the cited abstract, and that citation was the record ONLY reference, so nothing else propped it up. Re-sourced to PMID:9737817, 20 healthy male volunteers at steady state: half-life corrected 8 -> 9.8 h. V 317 L is DERIVED and flagged as such, from that same paper verbatim apparent clearance of 22.4 L/h and its half-life; because it is apparent, F is pinned to 1 and the stored 0.7 is dropped rather than paired with it. ka 1 /h dropped; the 1.8 h beside it is a time to peak, not a rate.
Pharmacokinetics
- Oral — t½ 9.8 h · F 100% · Vd 317 L
Sources: PMID:9737817