Ibuprofen
Ibuprofen. Reversible non-selective arachidonic acid cascade COX inhibitor. Reduces prostaglandin synthesis → analgesia, anti-inflammation… Oral half-life 1.9 h.
Reversible non-selective Arachidonic acid cascade COX inhibitor. Reduces prostaglandin synthesis → analgesia, anti-inflammation, antipyresis. Reversibility means antiplatelet effect is dose-dependent + reversible (unlike Aspirin's irreversible acetylation).
PK: V 10 L IS THE DOSE — the cited study gave "single dose 10 mg; double dose 20 mg total", against a therapeutic 200 to 800 mg, in ELDERLY subjects sampled for only six hours. THIS RECORD OWN REFERENCE CONTAINS THE SENTENCE THAT INVALIDATES ITS PHARMACOKINETIC BLOCK: "data generated using nonstereospecific assays may not be extrapolated to explain the disposition of the individual enantiomers", with substantial unidirectional inversion of the inactive R-enantiomer to the active S. Every stored value describes racemic total drug. ka 2 was refuted by its own citation, predicting a 1.04 h peak against a stated 1.6-1.8 h; a genuine published rate of 1.52 /h now replaces it, alongside a summed apparent volume from the same fit. F is pinned to 1 because absolute bioavailability is essentially complete at 102.7% — which is also why THE INTRAVENOUS ROW IS KEPT AND GIVEN THE SAME VOLUME: at complete bioavailability the oral apparent volume is the true one, so it transfers legitimately even though the cited study ran no intravenous arm. The transdermal route is removed as declared with no parameters and no citation. The effect-compartment value verifies and is the one sound number the record already had.
Pharmacokinetics
- Oral — t½ 1.9 h · F 100% · ka 1.52 h⁻¹ · Vd 9.3 L
- IV — t½ 1.9 h · F 100% · Vd 9.3 L
Related compounds
- Acetaminophen — synergistic
- Apixaban — caution
- Aspirin — caution
- Dabigatran — caution
- Rivaroxaban — caution
- Warfarin — caution
Sources: PMID:9515184, PMID:2724076, PMID:11678782, PMID:2109643, PMID:8229677