IGF-1 LR3

peptide · endocrine · Subcutaneous

IGF-1 LR3, a peptide. 70-aa native IGF-1 with (1) N-terminal 13-aa extension from maize IGF-1-like sequence and (2) Arg-3 substitution — together they reduce binding…

70-aa native IGF-1 with (1) N-terminal 13-aa extension from maize IGF-1-like sequence and (2) Arg-3 substitution — together they reduce binding to IGFBPs → more free/bioactive IGF-1 and much longer tissue retention than native IGF-1 (~20 min half-life vs LR3 ~30 h). Originally developed for cell-culture use; popular in research/athletic circles for muscle anabolism.

Sources: PMID:7752586