Imipramine
Imipramine. Tertiary-amine TCA — first TCA approved (1959). Approved for depression + childhood enuresis. Active desipramine metabolite.… Oral half-life 16 h.
Tertiary-amine TCA — first TCA approved (1959). Approved for depression + childhood enuresis. Active desipramine metabolite. Anticholinergic burden + cardiotoxicity at overdose are class issues.
PK: THE SURVIVING HALF OF A CONFIRMED CLASS DEFAULT. ka 1.5 was deleted from desipramine last batch as a tricyclic default propagated across records; IT SITS ON TWENTY-FIVE RECORDS in this catalog, including 5-htp, allopurinol, glycine, lsd, warfarin and theophylline, and is deleted here too. MY PRIOR ABOUT F WAS CONFIRMED IN BOTH DIRECTIONS: the value genuinely is imipramine own — "Comparison of i.v. and p.o. imipramine doses indicated absolute bioavailability was 40.2% in the control state", an intravenous-plus-oral crossover in the same six volunteers — but it was attributed to a paper that does not contain it, and the paper that does was not in refs[] at all. The whole record now moves to that study control arm, which is the only internally consistent set in this literature: its stated clearance and its volume and half-life agree to 1.4%, and its stated oral AUC to 4.4%. It is also INTRAVENOUS-ANCHORED, which acquits class 6 — the volume is absolute, so pairing it with F is correct. The half-life 16.7 was verbatim and correctly attributed, and the word "from" in "a prolongation in imipramine half-life (from 16.7 +/- 3.3 to 19.2 +/- 5.4 h)" fixes the control arm unambiguously; it moves only to keep one coherent set. A CAVEAT IS LOGGED: the two papers disagree about 1.9x on clearance, and mixing them is what produced the 41% error.
Pharmacokinetics
- Oral — t½ 15.5 h · F 40% · Vd 1386 L
Sources: PMID:8333005, PMID:6726654, PMID:9088587