Infliximab

biologic · immune-hematologic · IV

Infliximab, a biologic. Chimeric IgG1 mAb (~75% human Fc / 25% murine Fv) binding soluble and transmembrane TNFα with high affinity; induces reverse… IV half-life 9 d.

Chimeric IgG1 mAb (~75% human Fc / 25% murine Fv) binding soluble and transmembrane TNFα with high affinity; induces reverse signalling and apoptosis of TNF-expressing T cells and macrophages. First anti-TNF approved. Combining with MTX reduces immunogenicity and improves durability.

Pharmacokinetics

• IV — t½ 9.0 d · F 100% · Vd 4.2 L

Sources: PMID:17655372, PMID:20519961