Irbesartan

pharmacological · renal · Oral

Irbesartan. AT1 receptor blocker — strong renoprotection signal in IDNT trial for diabetic nephropathy. Once-daily dosing. Oral half-life 13 h.

AT1 receptor blocker — strong renoprotection signal in IDNT trial for diabetic nephropathy. Once-daily dosing.

PK: THE STORED 14 h WAS A STANDARD DEVIATION. Its paper reports 20.21 plus or minus 14.71, and the second number was stored as the half-life — a new collision shape, a dispersion statistic read as a central value. Re-sourced to PMID:9725545, 18 healthy males dosed orally and intravenously, which states a half-life of 13 to 16 h, a steady-state volume of 53 to 93 L and a bioavailability of 60 to 80%; the stated LOWER endpoints are stored, and the previous F of 0.7 was that range midpoint. ka 1.5 /h dropped as a Tmax collision, the cited paper time to peak being 1.44 h.

Pharmacokinetics

• Oral — t½ 13 h · F 60% · Vd 53 L

Sources: PMID:9246947, PMID:9725545