J-147

pharmacological · nervous · Oral

J-147. Investigational small molecule studied in preclinical models of aging and neurodegeneration; mitochondrial ATP synthase has been investigated as a target.

Investigational small molecule studied in preclinical models of aging and neurodegeneration; mitochondrial ATP synthase has been investigated as a target.

ROUTE: Oral activity in the cited study was demonstrated in mice. In vitro metabolism and animal findings do not establish a human regimen. PK FULL TEXT: PMID:23673233 Results and Fig. 5 report mouse plasma half-life 1.5 h, brain half-life 2.5 h and oral bioavailability 28%. These animal values are not assigned to a human model.

Sources: PMID:23673233, PMID:29316249, PMID:23582448