Kaempferol

flavonoid · digestive · Oral

Kaempferol, a flavonoid. Flavonol with ER-α binding (weak phytoestrogen activity), Nrf2 activation, and mTOR inhibition. Gut-microbial conversion… Oral half-life 4 h.

Flavonol with ER-α binding (weak phytoestrogen activity), Nrf2 activation, and mTOR inhibition. Gut-microbial conversion yields phloroglucinol-type metabolites. Anti-angiogenic effects reported in tumour models (VEGF pathway modulation).

Pharmacokinetics

• Oral — t½ 4 h · F 2% · ka 1.095 h⁻¹ · Vd 84 L

Sources: PMID:15113710