Ketone Ester (ΔG)

ketone · nervous · Oral

Ketone Ester (ΔG), a ketone. Designed by Kieran Clarke / DARPA (Oxford, 2008) and commercialised as HVMN Ketone. Two R-stereocenters — one on the… Oral half-life 2 h.

Designed by Kieran Clarke / DARPA (Oxford, 2008) and commercialised as HVMN Ketone. Two R-stereocenters — one on the BHB arm, one on the butanediol arm. Hydrolysed in the gut to R-BHB + R-1,3-butanediol; the latter is then liver-converted to another R-BHB. Net: 2 mol R-BHB per 1 mol ester. Raises plasma BHB to 2–5 mmol/L — much higher than salts. Pure R-form avoids the L-BHB ballast of racemic salts, and no cation load.

Pharmacokinetics

• Oral — t½ 2 h · F 95%

Related compounds

• R,S-1,3-Butanediol Ester of β-Hydroxybutyrate — synergistic

Sources: PMID:22561291