Ketoprofen
Ketoprofen. Non-selective (COX-1-preferential in whole blood) propionic-acid NSAID; short t½, dosed TID (IR) or once-daily (ER).… Oral half-life 2.1 h.
Non-selective (COX-1-preferential in whole blood) propionic-acid NSAID; short t½, dosed TID (IR) or once-daily (ER). Analgesic/anti-inflammatory.
PK: ka 2.13 IS THE CLEANEST BACK-DERIVATION IN THIS BATCH - with the stored half-life it solves to Tmax 0.9996 h, landing on exactly one hour, where the cited abstract real peak times are "72 +/- 45" and "61 +/- 39" MINUTES. F 0.95 becomes the measured absolute figure, and the enantiomer question is handled explicitly rather than averaged away: "The absolute bioavailability of the 50 mg oral dose was 84.5 (s.d. 20.6) % and 81.4 (18.0) % for R-ketoprofen and S-ketoprofen, respectively". NO RACEMATE FIGURE IS STATED, so no mean is taken; the stored value is the S-enantiomer, which carries the pharmacology, and the R value is recorded here. t-half 1.9 becomes 2.05 h, verbatim and INTRAVENOUS, which pairs coherently with the volume and clearance from the same study. V 15 L IS ACQUITTED AND I NEARLY FLAGGED IT WRONGLY: it is a back-derivation, but from intravenous data - that study clearance of 5.10 L/h divided by the rate implied by its own 2.05 h half-life gives 15.08 - so the magnitude is right and the pairing with an independent F is NOT a class-6 defect. THE WHOLE-BLOOD QUESTION IS SETTLED IN THE OCCUPANCY ROWS AND HAS NO PK ANALOGUE: both COX values were re-read from the source table directly and both conversions check exactly.
Pharmacokinetics
- Oral — t½ 2 h · F 81% · Vd 15 L
Sources: PMID:7262174, PMID:10377455, PMID:9353694, PMID:8527271, PMID:3581635