Kisspeptin
Kisspeptin, a peptide. Upstream master regulator of GnRH release — activates KISS1R (GPR54) on hypothalamic GnRH neurons. Critical for… IV half-life 0.5 h.
Upstream master regulator of GnRH release — activates KISS1R (GPR54) on hypothalamic GnRH neurons. Critical for reproductive-axis initiation (puberty) and maintenance. Proposed clinical uses include hypogonadotropic hypogonadism, IVF ovulation trigger (bypasses some HCG safety concerns), and PCOS research.
PK is KISSPEPTIN-54 specific. Dhillo 2005 (PMID:16174713), 6 male volunteers, 90-minute IV infusion, verbatim "The plasma half-life of kisspeptin-54 was calculated to be 27.6 +/- 1.1 min" (0.46 h) and "the volume of distribution was 128.9 +/- 12.5 ml/kg" — 9 L at 70 kg, added 2026-09-06 along with the clearance figure of 3.2 mL/kg/min. Both are absolute, from an IV infusion, so they pair safely. IDENTITY CAVEAT: this record carries an unqualified name while every value describes the 54-residue form; the separate kisspeptin-10 record is correctly marked as having no PK of its own, and a consumer must not apply these numbers to the 10-mer.
Pharmacokinetics
- IV — t½ 28 min · F 100% · Vd 9 L
Related compounds
- Kisspeptin-10 — synergistic
Sources: PMID:26192876