L-β-Hydroxybutyrate

ketone · nervous · musculoskeletal · Oral

L-β-Hydroxybutyrate, a ketone. The non-natural enantiomer. Not a fuel substrate — BDH1 (β-hydroxybutyrate dehydrogenase) is stereospecific for R-BHB. L-BHB retains…

The non-natural enantiomer. Not a fuel substrate — BDH1 (β-hydroxybutyrate dehydrogenase) is stereospecific for R-BHB. L-BHB retains HDAC inhibition (weaker) and some signalling activity but does not produce ATP. Cleared more slowly than R-BHB → can accumulate after repeated racemic-salt dosing.

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