Larazotide
Larazotide, a peptide. Zonulin antagonist octapeptide — blocks zonulin-induced tight-junction disassembly in gut epithelium. Trialed for celiac… Oral half-life 1 h.
Zonulin antagonist octapeptide — blocks zonulin-induced tight-junction disassembly in gut epithelium. Trialed for celiac disease as adjunct to gluten-free diet (failed Phase 3 in 2022); biohacker / leaky-gut interest persists.