Leucine

amino-acid · musculoskeletal · Oral

Leucine, an amino acid. The only AA that directly activates mTORC1 via the Rag-GTPase/Sestrin2/Leucyl-tRNA synthetase pathway. Key trigger of muscle protein synthesis…

The only AA that directly activates mTORC1 via the Rag-GTPase/Sestrin2/Leucyl-tRNA synthetase pathway. Key trigger of muscle protein synthesis (MPS). HMB (β-hydroxy-β-methylbutyrate) is its downstream metabolite and anti-catabolic marker. Ketogenic.