Levofloxacin
Levofloxacin. Respiratory fluoroquinolone — S-enantiomer of ofloxacin. Inhibits bacterial DNA gyrase + topoisomerase IV. Better gram-positive… Oral half-life 6.5 h.
Respiratory fluoroquinolone — S-enantiomer of ofloxacin. Inhibits bacterial DNA gyrase + topoisomerase IV. Better gram-positive (S. pneumoniae) coverage than ciprofloxacin. Same fluoroquinolone class warnings: tendinopathy, neuropathy, QT prolongation, aortopathy.
PK: the cleanest zero-content case in its group — the cited paper reports only dose-normalised peak and exposure, and supports NONE of its seven values. The stored 7 h was a review range endpoint ("7 to 8 hours"), not a measurement; the real intravenous half-life at 500 mg is 6.5 h (PMID:16255991), rising to 7.75 h at 750 mg, so it is dose-specific. F 0.99 was RIGHT but wrongly cited; it belongs to Chien 1997 (PMID:9333057), 24 healthy men in a three-way oral-versus-intravenous crossover, verbatim "mean absolute bioavailability of > or =99%". No healthy-volunteer intravenous volume exists in any abstract, so V 101.71 L is APPARENT and F is pinned to 1 — which costs almost nothing here precisely because the real F is 99%. That paper also confirms the routes are interchangeable.
Pharmacokinetics
- Oral — t½ 6.5 h · F 100% · Vd 101.71 L
- IV — t½ 6.5 h · F 100% · Vd 101.71 L
Sources: PMID:22404324, PMID:9333057, PMID:16255991, PMID:29947489