Levotetrahydropalmatine

alkaloid · nervous · cardiovascular · Oral

Levotetrahydropalmatine, an alkaloid. The levorotatory tetrahydropalmatine enantiomer, also called rotundine, studied for sedative effects.… Oral half-life 13 h.

The levorotatory tetrahydropalmatine enantiomer, also called rotundine, studied for sedative effects. Poisoning and severe toxicity have been reported.

IDENTITY: L-THP refers to the levorotatory form; distinguish it from racemic tetrahydropalmatine and salt forms. PK FULL TEXT: PMID:27363313 Table 3 supports a 13.3 h geometric mean terminal half-life in a narrowly defined study population. Absolute F and V remain unknown. DOSE: Study participants received 30 mg orally every 12 h for seven doses; this is a study regimen.

Pharmacokinetics

• Oral — t½ 13.3 h

Sources: PMID:42519822, PMID:14294852, PMID:27363313