Lisdexamfetamine
Lisdexamfetamine, a stimulant. Inactive prodrug — L-lysine conjugated to d-amphetamine. Cleaved by RBC peptidases to release active… Oral half-life 17 h.
Inactive prodrug — L-lysine conjugated to d-amphetamine. Cleaved by RBC peptidases to release active d-amphetamine. Enzymatic conversion is rate-limiting → flatter PK than immediate-release dextroamphetamine (lower Cmax, longer duration, less abuse potential when snorted/injected since conversion requires erythrocytes).
ANALYTE: DEXTROAMPHETAMINE, and the cleanest discrimination of the nine — one abstract, same subjects, both species: lisdexamfetamine "half-life [t1/2] = 0.5 hours" against d-amphetamine "t1/2 = 17.0 hours", a THIRTY-FOUR-FOLD split. The stored 11.6 h could only be the metabolite, and is corrected to the verbatim 17.0. CITATION DEFECT: the previous source reports no half-life, no bioavailability and no volume, though it does confirm the analyte by measuring "Plasma concentrations of amphetamine". THE WORST DOSE-BASIS RATIO OF THE BATCH: mw 263.38 is the lysine conjugate while d-amphetamine is 135.21, so a dose converts to moles about 1.95x too high. MASS: the stored molecular weight described the PARENT while pk_analyte declares the metabolite, so the one field that must name a single species named the wrong one. LATENT RATHER THAN LIVE — this record carries no occupancy rows and is no other record interaction perpetrator — but it is one authored edge away from being live, because both consumers of the field (the micromolar-to-mass conversion for a kinetics edge, and the affinity the app renders from a stored occupancy concentration) want the species that actually circulates, which is the species pk[] already describes.
Pharmacokinetics
- Oral — t½ 17 h · F 96% · Vd 210 L
Sources: PMID:28936175, PMID:27935735