LSD

alkaloid · nervous · digestive · Oral · Sublingual

LSD, an alkaloid. Ergoline lysergamide derived from ergot alkaloids (Hofmann 1938). Very potent 5-HT2A agonist (Ki ~3.5 nM) plus partial… Oral half-life 3.6 h.

Ergoline lysergamide derived from ergot alkaloids (Hofmann 1938). Very potent 5-HT2A agonist (Ki ~3.5 nM) plus partial activity at 5-HT1A/1B/2C, D2, adrenergic. Unique binding kinetics — extended receptor-bound residence time gives the long clinical duration. Metabolised by CYP2D6 + CYP3A4 to inactive metabolites.

Pharmacokinetics

• Oral — t½ 3.6 h · F 70% · ka 1.607 h⁻¹ · Vd 28 L

Related compounds

• Psilocybin — caution

Sources: PMID:26108222