Lubiprostone

pharmacological · digestive · Oral

Lubiprostone. Selective ClC-2 chloride-channel activator on intestinal epithelium → enhanced fluid secretion. Used for chronic idiopathic constipation +…

Selective ClC-2 chloride-channel activator on intestinal epithelium → enhanced fluid secretion. Used for chronic idiopathic constipation + opioid-induced constipation. Nausea is the most common dose-limiting effect (taken with food helps).

Sources: PMID:36626291, PMID:22834474