Mazdutide
Mazdutide, a peptide. A once-weekly fatty-acylated synthetic analogue of oxyntomodulin acting as a balanced agonist at the GLP-1 receptor and the glucagon receptor.…
A once-weekly fatty-acylated synthetic analogue of oxyntomodulin acting as a balanced agonist at the GLP-1 receptor and the glucagon receptor. PMID:35750681 full text verbatim: "IBI362 (also known as LY3305677) is a once-weekly synthetic peptide analogue of mammalian OXM, with a fatty-acyl moiety to extend the half-life." The same paper's statement that it "potently bound to human and mouse GLP-1 receptors and glucagon receptors in vitro" carries NO NUMBER and cites other references, so it is a secondary citation for affinity and no occupancy row is authored.
PubChem CID 167312357 (C207H317N45O65, 4476), re-queried 2026-09-26. At 4.5 kDa it sits in the 3-10 kDa band where the direction of the volume error is unknown, so no volume is guessed. TWO TRAPS IN THE SOURCES, both recorded so they are not imported. (1) AN INTERNAL INCONSISTENCY IN PMID:35750681: the sentence "IBI362 demonstrated slow absorption with peak concentrations (C max ) achieved ranging from 23.3 hours to 144.2 hours" gives those figures in HOURS and the next clause gives "the median T max is ~72 hours" — it is describing time-to-peak, not a concentration, so there is NO Cmax value in that text and none may be read out of it. (2) AN ANALYTE TRAP IN PMID:40832785: the only Cmax and tmax numbers in that paper are ACETAMINOPHEN's, from a gastric-emptying substudy, and none of them may be attributed to mazdutide. DOSES, verbatim once-weekly subcutaneous: "once-weekly IBI362 (3.0 mg, 4.5 mg or 6.0 mg), placebo or open-label dulaglutide (1.5 mg) subcutaneously for 12 weeks" (PMID:35750681 — the 1.5 mg is DULAGLUTIDE, a comparator, not a mazdutide dose); escalation to 16 mg over 20 weeks (PMID:40832785); and the approved phase 3 doses, "4 mg of mazdutide, 6 mg of mazdutide, or placebo for 48 weeks" (PMID:40421736), which is why typical is 6 mg.
Sources: PMID:35750681, PMID:40832785, PMID:40421736