Medroxyprogesterone

hormone · endocrine · reproductive · Oral · Intramuscular

Medroxyprogesterone, a hormone. Synthetic progestin (17α-hydroxyprogesterone derivative). Agonizes the progesterone receptor; suppresses… Oral half-life 2.1 d.

Synthetic progestin (17α-hydroxyprogesterone derivative). Agonizes the progesterone receptor; suppresses pituitary LH/FSH to inhibit ovulation, thickens cervical mucus, transforms endometrium. Oral (HRT/amenorrhea/oncology) + IM depot (q3-month contraception).

F 0.9 REMOVED as an R6 stored default. PMID:2943134 compares SIX ORAL TABLET FORMULATIONS against each other with no IV arm: it is titled a bioavailability evaluation and is entirely RELATIVE bioavailability, which is a different quantity. No 90% appears in it. Numerically a no-op against the 0.9 default.

Pharmacokinetics

• Oral — t½ 2.1 d · ka 2.64 h⁻¹ · Vd 1000 L
• Intramuscular — t½ 2.1 d · F 100% · Vd 1000 L

Sources: PMID:2943134, PMID:1388093, PMID:2971841