Memantine

nootropic · nervous · Oral

Memantine, a nootropic. Uncompetitive NMDA receptor antagonist with low-to-moderate affinity — preferentially blocks pathologically… Oral half-life 2.9 d.

Uncompetitive NMDA receptor antagonist with low-to-moderate affinity — preferentially blocks pathologically over-activated channels while sparing physiologic glutamate signaling. FDA-approved for moderate-to-severe Alzheimer's disease.

Pharmacokinetics

• Oral — t½ 2.9 d · F 100% · ka 0.18 h⁻¹ · Vd 850 L

Sources: PMID:18498913