Meropenem

pharmacological · nervous · IV

Meropenem. Carbapenem β-lactam — very broad spectrum (gram-positive, gram-negative including Pseudomonas + ESBL producers, anaerobes). Reserved… IV half-life 0.8 h.

Carbapenem β-lactam — very broad spectrum (gram-positive, gram-negative including Pseudomonas + ESBL producers, anaerobes). Reserved for severe infections + ESBL-producing organisms. Lower seizure risk than imipenem.

PK: A GENUINE CONTROL WITH ONE ROUNDING FIX. The volume is verbatim in a sentence that also settles the arithmetic — "The mean plasma half-life of meropenem was 0.8 h, mean plasma clearance 277 ml/min and the mean volume of distribution 20.4 l" — and pinning bioavailability at unity is correct because that volume is intravenous-derived from a half-hour infusion in six healthy men. THE ROUNDED HALF-LIFE BROKE THE CLEARANCE TEST AGAINST ITS OWN CITATION by fifteen percent; the verbatim value from the same fit closes it to six, and the residual is the paper own rounding. The feasibility identity is CORRECTLY NOT APPLIED — for an intravenous-only record it degenerates into the clearance test and carries no independent information, so no second test was manufactured. AND THE PER-KILOGRAM DOSE SWEEP DOES NOT REACH THIS RECORD: flat adult dosing is correct here, the cited study used the stored minimum, the predicted peak matches the published one, and the only weight-based meropenem literature is paediatric.

Pharmacokinetics

Sources: PMID:2055812