Methamphetamine

stimulant · nervous · cardiovascular · Oral · Intranasal · Inhaled · IV

Methamphetamine, a stimulant. Potent monoamine releaser — a TAAR1 agonist that reverses DAT/NET and VMAT2 to dump dopamine and norepinephrine… Oral half-life 10 h.

Potent monoamine releaser — a TAAR1 agonist that reverses DAT/NET and VMAT2 to dump dopamine and norepinephrine into the synapse, producing prolonged CNS stimulation, euphoria, and wakefulness. More lipophilic and longer-acting than amphetamine; dopaminergic neurotoxicity and cardiovascular strain at high/chronic doses. Prescribed (Desoxyn) rarely for ADHD/obesity.

PubChem CID 10836. Releaser (substrate) — transporter occupancy + plasma t½ (~10–12 h) deferred to enrichment pass.

Pharmacokinetics

• Oral — t½ 10.1 h