Methocarbamol
Methocarbamol. Centrally-acting muscle relaxant — exact mechanism not well-defined; CNS depression contributes. Lower anticholinergic burden… Oral half-life 1.1 h.
Centrally-acting muscle relaxant — exact mechanism not well-defined; CNS depression contributes. Lower anticholinergic burden than cyclobenzaprine; preferred in elderly. Used for acute musculoskeletal pain.
PK: all four stored values were unsupported and the INTRAVENOUS ROW hung on an oral-only bioequivalence study, which is why that route is removed. Half-life re-sourced to Sica 1990 (PMID:2253675), 17 healthy male volunteers on 1.5 g orally, verbatim "The harmonic mean elimination half-life was similar between the two groups, 1.24 and 1.14 h" — the healthy-volunteer figure is stored. The previous citation reports only areas under the curve and peak concentrations; a bioequivalence study cannot yield an absolute bioavailability in any case. No human volume and no absolute bioavailability exist for methocarbamol in any abstract found.
Pharmacokinetics
- Oral — t½ 1.1 h
Sources: PMID:19537524, PMID:2253675