Methylprednisolone

hormone · endocrine · immune-hematologic · Oral · IV · Intramuscular

Methylprednisolone, a hormone. Synthetic 6α-methyl glucocorticoid; ~5× cortisol potency. Used in pulse therapy for severe inflammation… Oral half-life 3 h.

Synthetic 6α-methyl glucocorticoid; ~5× cortisol potency. Used in pulse therapy for severe inflammation (auto-immune flares, transplant rejection, MS exacerbations) where rapid IV onset matters.

Pharmacokinetics

• Oral — t½ 3 h · F 85% · ka 0.7897 h⁻¹ · Vd 90 L
• IV — t½ 3 h · F 100% · Vd 90 L

Sources: PMID:2655680