Mifepristone

hormone · endocrine · Oral

Mifepristone, a hormone. Progesterone receptor antagonist + glucocorticoid receptor antagonist. Combined with misoprostol for medical abortion… Oral half-life 18 h.

Progesterone receptor antagonist + glucocorticoid receptor antagonist. Combined with misoprostol for medical abortion (≤10 weeks). Korlym formulation for hyperglycemia in Cushing syndrome leverages the GR antagonism.

Pharmacokinetics

• Oral — t½ 18 h · F 40% · ka 2.018 h⁻¹ · Vd 103 L

Sources: PMID:11858883, PMID:8282004, PMID:12781197