Mixed Amphetamine Salts
Mixed Amphetamine Salts, a stimulant. 3:1 ratio of d- to l-amphetamine. L-enantiomer adds peripheral sympathomimetic activity (CV-effect… Oral half-life 10 h.
3:1 ratio of d- to l-amphetamine. L-enantiomer adds peripheral sympathomimetic activity (CV-effect contribution). XR formulation uses dual-bead profile for 10–12 h action.
F 0.9 REMOVED as an R6 stored default. PMID:34826114 lists its parameters explicitly — Cmax, tmax, AUC, t1/2, CL/F, apparent Vss — and states no bioavailability; being oral multiple-dose only it cannot. Separately worth knowing: that study is 24 CHILDREN aged 4-5, so it also does not support this record adult 70 kg-referenced volume. Numerically a no-op. ABSORPTION-RATE PROVENANCE: this value was derived by inverting the one-compartment peak-time relation in 2026-05-26-wave25-ka-from-tmax.ts, whose header claimed every peak time was verbatim from a primary human study. ALL FORTY-FOUR ENTRIES HAVE NOW BEEN CHECKED AND TWENTY-EIGHT FAIL. This one fails because the midpoint of a review range generic to all immediate-release amphetamine, not to this product. It is DISCLOSED RATHER THAN DELETED: a midpoint of a narrow range is usually inside the true spread, and removing it would fall back on the solver default of 1.0 per hour, which is worse for most of these records.
Pharmacokinetics
- Oral — t½ 10.4 h · ka 1.21 h⁻¹ · Vd 210 L
Sources: PMID:28936175, PMID:28910145