MOTS-c

peptide · endocrine · Subcutaneous · Intramuscular

MOTS-c, a peptide. Encoded within the mitochondrial 12S rRNA open reading frame — one of the first 'mitochondrial-derived peptides' characterised (Lee 2015).…

Encoded within the mitochondrial 12S rRNA open reading frame — one of the first 'mitochondrial-derived peptides' characterised (Lee 2015). Translocates to nucleus under metabolic stress; activates AMPK → modulates glycolytic + fatty-acid oxidation pathways. Declines with age. Exogenous administration improves insulin sensitivity and exercise capacity in rodent models.

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