Mycophenolate Mofetil

pharmacological · immune-hematologic · Oral · IV

Mycophenolate Mofetil. Prodrug of mycophenolic acid — selectively inhibits IMPDH2 (lymphocytes lack purine salvage and depend on de novo… Oral half-life 17 h.

Prodrug of mycophenolic acid — selectively inhibits IMPDH2 (lymphocytes lack purine salvage and depend on de novo synthesis). Suppresses B + T cell proliferation. Backbone of transplant immunosuppression alongside calcineurin inhibitors; also lupus nephritis induction therapy.

PK: WRONG ANALYTE, CONFIRMED BY MASS. The stored molecular weight of 433.5 is mycophenolate MOFETIL, the prodrug ester, while every measured value describes MYCOPHENOLIC ACID at 320.34 — the cited paper says so outright, and another states that "After oral administration, however, plasma MMF was below quantitation limits at all times". Any dose-to-mole conversion here is off by the 1.353 ester factor; that is a schema question and is logged, not silently changed. F 0.941 is real but belonged to PMID:8728345, "mean bioavailability of MPA from oral administration of MMF estimated as 94.1% relative to the intravenous route"; the cited paper 101.5% is a test-versus-reference FORMULATION RATIO. Half-life 17 h from the same paper, explicitly route-independent. V 40 L is dropped: it is roughly eight times smaller than the only published volume, and that one is apparent. ENTEROHEPATIC RECIRCULATION: a secondary peak at 8 to 12 hours contributes about 40% of exposure, and no single first-order absorption term can reproduce it — which is why the stored rate of 4, though within rounding of a real published 4.1, is dropped rather than kept. MASS: the stored molecular weight described the PARENT while pk_analyte declares the metabolite, so the one field that must name a single species named the wrong one. LATENT RATHER THAN LIVE — this record carries no occupancy rows and is no other record interaction perpetrator — but it is one authored edge away from being live, because both consumers of the field (the micromolar-to-mass conversion for a kinetics edge, and the affinity the app renders from a stored occupancy concentration) want the species that actually circulates, which is the species pk[] already describes.

Pharmacokinetics

Sources: PMID:8728345