Naproxen

pharmacological · musculoskeletal · cardiovascular · Oral

Naproxen. Reversible non-selective COX inhibitor. Favorable long t½ (~15 h) → twice-daily dosing. CV safety profile reportedly better than other… Oral half-life 18 h.

Reversible non-selective COX inhibitor. Favorable long t½ (~15 h) → twice-daily dosing. CV safety profile reportedly better than other NSAIDs in meta-analyses (PRECISION trial).

PK: THE CITATION WAS BOTH EMPTY AND THE WRONG FORMULATION. PMID:26257511 reports only Cmax and AUC, none of the four stored values, and HCP1004 and VIMOVO are fixed-dose combinations of ENTERIC-COATED naproxen with esomeprazole - a delayed-release product cited on an immediate-release row, the nifedipine defect in milder form. t-half 15 was a RANGE ENDPOINT lifted from a review "naproxen (12-15 h)" and becomes the verbatim "the elimination half-life of naproxen was 17.7 +/- 3.0 h" from eight healthy subjects on a single oral dose. V 12 L and F 0.95 are retained and declared: no verbatim human naproxen volume in litres exists in any abstract - the nearest statement is a class-wide inequality, "Volume of distribution is mostly low (less than 0.2 L/kg)" - and the only 95% figure in this literature is a RELATIVE one, "the bioavailability of naproxen in the suppositories was 94.8%+/-6.3% OF the bioavailability of naproxen in the tablets", which is a live collision candidate rather than a source. BOTH COX ROWS VERIFY and the whole-blood exemption is justified: "ex vivo IC50 values of 35.48 micromol/l (COX-1) and 64.62 micromol/l (COX-2)", "measured ex vivo in human whole blood". OUR OWN PROSE WAS WRONG: the warfarin interaction note credits PMID:2724076 to Chan 1989; the paper is Diana, Veronich and Kapoor. THE WARFARIN INTERACTION NOTE MISCREDITS ITS SOURCE: PMID:2724076 is credited to "Chan 1989" and is in fact Diana, Veronich and Kapoor, J Pharm Sci 1989. The quoted displacement figures, free warfarin 9-24% against 2.5-6%, ARE verbatim and the interaction itself is correctly filed. PK: THE STORED ABSORPTION RATE WAS THE SOLVER DEFAULT WEARING A CITATION. A ka of 1.0/h is exactly what resolvePk substitutes when the field is ABSENT, and no source on this record states one. Removing it is NUMERICALLY A NO-OP — the resolver supplies the identical number — so no curve moves; what changes is that the record stops asserting an absorption rate it never measured. This is the same shape already found on a volume of 35 L, which is likewise the default at the seventy-kilogram reference. THE WIDER DEBT IS LEFT ALONE ON PURPOSE: twelve values account for 152 of the 276 authored absorption rates, but the other eleven are NOT the default, so deleting those would move their curves rather than leave them, which is the error this audit spent a batch documenting.

Pharmacokinetics

Related compounds

Sources: PMID:9113437, PMID:2724076, PMID:18397691, PMID:7439246