Niacin

vitamin · cardiovascular · integumentary · Oral

Niacin, a vitamin. Precursor to NAD⁺ and NADP⁺ (via the de-novo Preiss-Handler pathway or NAMPT-mediated salvage from nicotinamide… Oral half-life 0.9 h.

Precursor to NAD⁺ and NADP⁺ (via the de-novo Preiss-Handler pathway or NAMPT-mediated salvage from nicotinamide riboside/NMN). At pharmacologic doses (≥500 mg), activates the HCA2 (GPR109A) receptor on adipocytes → lowers lipolysis and FFA flux → reduces VLDL/LDL and raises HDL. The same receptor triggers the characteristic cutaneous flush via prostaglandin D2 release.

Pharmacokinetics

• Oral — t½ 54 min · F 80% · Vd 70 L

Related compounds

• NMN — synergistic

Sources: PMID:12901025