Niacinamide (topical)

topical · integumentary · immune-hematologic · Transdermal · Oral

Niacinamide (topical), a topical compound. Topical niacinamide reduces melanosome transfer from melanocytes to keratinocytes (hyperpigmentation reduction), improves…

Topical niacinamide reduces melanosome transfer from melanocytes to keratinocytes (hyperpigmentation reduction), improves epidermal barrier via ceramide synthesis, reduces transepidermal water loss, and has anti-inflammatory properties. Oral nicotinamide reduces non-melanoma skin cancer incidence (ONTRAC trial 500 mg BID).