Nilotinib

pharmacological · digestive · Oral

Nilotinib. Second-generation BCR-ABL tyrosine kinase inhibitor; ~30× imatinib potency. Used in imatinib-resistant or front-line CML. Strong CYP3A4 inhibitor; QT…

Second-generation BCR-ABL tyrosine kinase inhibitor; ~30× imatinib potency. Used in imatinib-resistant or front-line CML. Strong CYP3A4 inhibitor; QT prolongation black-box. Food triples Cmax — must be taken fasted.

Sources: PMID:21184622, PMID:15710326, PMID:21827214, PMID:21419933, PMID:40349288