Nimodipine
Nimodipine. Highly lipophilic dihydropyridine CCB — preferential cerebrovascular vasodilation. FDA-approved for prevention of vasospasm-related… Oral half-life 2.9 h.
Highly lipophilic dihydropyridine CCB — preferential cerebrovascular vasodilation. FDA-approved for prevention of vasospasm-related neurologic deficits after subarachnoid hemorrhage. Hypotension at high doses limits use.
PK: MY FORMULATION PRIOR DOES NOT REPEAT - THE RECORD ALREADY GOT THAT RIGHT. The cited study compared regular 30 mg every 6 h against a programmed-action 120 mg every 24 h, and the record took the IMMEDIATE-RELEASE arm, correctly leaving the modified-release "Apparent half-life ... in 17.8 h" alone. This is not nifedipine. The real defect is CLASS 12, and the cited paper refutes the record with its own data: {V 1300, F 0.13} gives an effective V/F of 10,000 L, and simulating that paper own regimen predicts a steady-state Cmax of 2.5 ng/mL against its observed "10.208 +/- 0.317 ng/ml" - FOUR TIMES LOW - while its data imply V/F near 2,500 L. THE TWO NUMBERS HAD TO MOVE TOGETHER: setting F to the real absolute figure while leaving V at 1300 would have made V/F 24,000 and the error nearly TEN times, worse than before. So F is pinned to 1 and the volume becomes the apparent V/F the citation own observations support, with the measured absolute bioavailability recorded here instead: "The absolute bioavailability was 10.6/1.60% in the elderly and 5.4/2.11% in young subjects", which is exactly the 5-13% spread and shows the stored 0.13 was above both arms. t-half 2.9 is verbatim but is NOT a consensus value - the literature spans 7 min and 1 h intravenously, 9.1 h orally and a review 13 h - and is kept because it is the cited paper own number. PK: THE STORED ABSORPTION RATE WAS THE SOLVER DEFAULT WEARING A CITATION. A ka of 1.0/h is exactly what resolvePk substitutes when the field is ABSENT, and no source on this record states one. Removing it is NUMERICALLY A NO-OP — the resolver supplies the identical number — so no curve moves; what changes is that the record stops asserting an absorption rate it never measured. This is the same shape already found on a volume of 35 L, which is likewise the default at the seventy-kilogram reference. THE WIDER DEBT IS LEFT ALONE ON PURPOSE: twelve values account for 152 of the 276 authored absorption rates, but the other eleven are NOT the default, so deleting those would move their curves rather than leave them, which is the error this audit spent a batch documenting.
Pharmacokinetics
- Oral — t½ 2.9 h · F 100% · Vd 2500 L
Sources: PMID:11986913, PMID:6300912, PMID:8832305