Ostarine

pharmacological · endocrine · reproductive · musculoskeletal · Oral

Ostarine. First-generation non-steroidal SARM. Gentle AR activation producing muscle anabolism + bone density with minimal prostate / virilising effects. The…

First-generation non-steroidal SARM. Gentle AR activation producing muscle anabolism + bone density with minimal prostate / virilising effects. The most-studied SARM in human trials (POWER trials in NSCLC + breast cancer cachexia).

PK: STRIPPED. THE CITED PAPER CONTAINS ONLY RELATIVE QUANTITIES — "reduced the maximal plasma concentration (Cmax) by 23 % and the area under the curve (AUC-infinity) by 43 %" and similar fold-changes for four other perpetrators — WHICH IS THE CLASS-2 TRAP IN ITS PUREST FORM: a percentage change is not a parameter, and no absolute half-life, volume or bioavailability appears anywhere in it. The stored half-life is also a round twenty-four hours, the shape a template value takes. Searching the indexed literature returns one disposition study and IT IS IN RATS — "moderate plasma clearance (117.7 and 74.5 mL/h/kg) and mean elimination half-life of 0.6 h and 16.4 h in male and female rats" — a difference of twenty-seven fold between the sexes of one species, which is itself a reason not to extrapolate. Same verdict as lgd-4033 and s23.

Sources: PMID:27105861