Oxycodone
Oxycodone. µ-opioid receptor agonist with some κ-opioid activity. Unlike hydrocodone, oxycodone itself is active (doesn't require CYP2D6… Oral half-life 2.6 h.
µ-opioid receptor agonist with some κ-opioid activity. Unlike hydrocodone, oxycodone itself is active (doesn't require CYP2D6 conversion). Oxymorphone is an active metabolite.
PK: the intravenous row was a route error of a subtle kind — the cited study parenteral arm was INTRAMUSCULAR, not intravenous. F 0.60 survives intact but must be read as RELATIVE TO INTRAMUSCULAR dosing rather than absolute. The intravenous row is re-sourced to PMID:9062618, ten healthy volunteers on a 0.05 mg/kg bolus, giving a half-life of 157 minutes (2.6 h, replacing 3.5 h on both rows) and a steady-state volume of 2.02 L/kg, which is 141 L at 70 kg and is a true intravenous volume. ka 2.5 /h dropped; the only timing in the source is a median Tmax of 1 h. An elderly parameterisation exists as a matched pair (3.1 h with 277 L, PMID:18473019) and must be taken whole or not at all.
Pharmacokinetics
- Oral — t½ 2.6 h · F 60% · Vd 141 L
- IV — t½ 2.6 h · F 100% · Vd 141 L
Sources: PMID:8492004, PMID:9062618, PMID:8249052