Oxymorphone

alkaloid · nervous · digestive · Oral · IV · Intramuscular

Oxymorphone, an alkaloid. Semi-synthetic μ-opioid agonist; ~10× morphine potency PO, ~2× IV. Active metabolite of oxycodone via CYP2D6.… Oral half-life 9 h.

Semi-synthetic μ-opioid agonist; ~10× morphine potency PO, ~2× IV. Active metabolite of oxycodone via CYP2D6. Reformulated extended-release version (2017) reduces IV abuse but didn't prevent pivot to other agents.

Pharmacokinetics

• Oral — t½ 9 h · F 10% · Vd 210 L
• IV — t½ 9 h · F 100% · Vd 210 L

Sources: PMID:17658959