Pantethine

vitamin · cardiovascular · Oral

Pantethine, a vitamin. Dimeric disulfide form of pantetheine, the immediate CoA precursor (one step from CoA vs. three from pantothenic acid).… Oral half-life 0.1 h.

Dimeric disulfide form of pantetheine, the immediate CoA precursor (one step from CoA vs. three from pantothenic acid). Proposed dyslipidemia mechanism is inhibition of HMG-CoA reductase and acyl-CoA:cholesterol acyltransferase (ACAT) at the pantetheine stage.

Pharmacokinetics

• Oral — t½ 4 min · F 50%

Related compounds

• Pantothenic acid (B5) — synergistic

Sources: PMID:21925346, PMID:4056044