PE22-28

peptide · nervous · Subcutaneous

PE22-28, a peptide. 7-residue fragment of spadin (a naturally occurring TREK-1 inhibitor). TREK-1 is a two-pore-domain K⁺ channel highly expressed in prefrontal…

7-residue fragment of spadin (a naturally occurring TREK-1 inhibitor). TREK-1 is a two-pore-domain K⁺ channel highly expressed in prefrontal cortex + hippocampus; blocking it produces rapid antidepressant effects similar to SSRIs in rodent models — without the delay to onset. Limited human data.