Penicillin V
Penicillin V. Acid-stable orally-absorbed penicillin — inhibits bacterial transpeptidase (PBPs) crosslinking peptidoglycan. Streptococcal… Oral half-life 0.9 h.
Acid-stable orally-absorbed penicillin — inhibits bacterial transpeptidase (PBPs) crosslinking peptidoglycan. Streptococcal coverage for strep pharyngitis, secondary prophylaxis of rheumatic fever, dental prophylaxis (where indicated). Renal-cleared.
PK: THE INTRAVENOUS ROUTE IS REMOVED BECAUSE THE PRODUCT DOES NOT EXIST — parenteral penicillin is penicillin G, and no marketed intravenous phenoxymethylpenicillin exists to model. Re-sourced to Overbosch 1985 (PMID:3924086), verbatim "The volume of distribution in the steady state of PM was 35.41" and "the absorption after oral administration of PM as the acid was 48% and that of the potassium salt of PE was 86% of the dose"; the stored F 0.6 was neither. The half-life of 0.86 h is DERIVED and flagged as such, from that same paper own steady-state volume and its clearance of 476.4 ml/min — no PubMed abstract states a human phenoxymethylpenicillin half-life at all. Subjects were patients rather than healthy volunteers and clearance tracked creatinine clearance, so the value holds only at normal renal function. ka 1 /h dropped; the 0.81 h beside it is a Tmax.
Pharmacokinetics
- Oral — t½ 52 min · F 48% · Vd 35.41 L
Sources: PMID:2515160, PMID:3924086