Permethrin

topical · integumentary · Transdermal

Permethrin, a topical compound. Pyrethroid neurotoxin for arthropods — prolongs Na+ channel opening at insect / arachnid synapses →… Transdermal half-life 24 h.

Pyrethroid neurotoxin for arthropods — prolongs Na+ channel opening at insect / arachnid synapses → paralysis + death. Topical 1% for head lice, 5% for scabies. Mammalian toxicity is low (Na+ channel selectivity favors insects).