Phylloquinone

vitamin · digestive · immune-hematologic · Oral · IV · Intramuscular

Phylloquinone, a vitamin. Cofactor for γ-glutamyl carboxylase, which γ-carboxylates glutamate residues on vitamin-K-dependent proteins… Oral half-life 1.5 h.

Cofactor for γ-glutamyl carboxylase, which γ-carboxylates glutamate residues on vitamin-K-dependent proteins (coagulation factors II, VII, IX, X; protein C/S; osteocalcin; matrix Gla protein). The reduced (hydroquinone) form is oxidised during carboxylation and recycled by vitamin-K epoxide reductase (VKOR, blocked by warfarin). K1 is predominantly hepatic → clotting factors.

Pharmacokinetics

• Oral — t½ 1.5 h · F 10% · Vd 10.5 L
• IV — t½ 1.5 h · F 100% · Vd 10.5 L

Related compounds

• Warfarin — major
• Menadione — synergistic

Sources: PMID:17158229, PMID:15911722