Pimecrolimus

topical · integumentary · immune-hematologic · Transdermal

Pimecrolimus, a topical compound. Topical calcineurin inhibitor — same FKBP-12 / calcineurin pathway as tacrolimus, slightly less potent… Transdermal half-life 12 h.

Topical calcineurin inhibitor — same FKBP-12 / calcineurin pathway as tacrolimus, slightly less potent and lower systemic absorption. Approved for mild-to-moderate atopic dermatitis as a steroid alternative. Same FDA black-box (theoretical lymphoma).