Pindolol
Pindolol. Non-selective β-adrenergic blocker with intrinsic sympathomimetic activity (partial agonism) — less bradycardia + less peripheral… Oral half-life 4.7 h.
Non-selective β-adrenergic blocker with intrinsic sympathomimetic activity (partial agonism) — less bradycardia + less peripheral vasoconstriction than pure antagonists. Off-label augmentation strategy in SSRI-resistant depression.
PK: THE HALF-LIFE BELONGED TO TWO OTHER DRUGS. The cited abstract states NO half-life; what it gives is a control elimination constant, "ke: 1.43 +/- 0.46 h-1 vs 0.56 +/- 0.10 h-1", whose control value implies 1.24 h and therefore ACTIVELY CONTRADICTS the stored 4. Meanwhile searching pindolol surfaces three abstracts on MEPINDOLOL and BOPINDOLOL - different drugs in the same class - reporting "half-life of disposition was 4.0 +/- 1.5 h", "4-5 h" and "about 4 h", any of which would produce exactly 4. It becomes 4.7, verbatim in a true pindolol study: "The plasma elimination half-life was identical after SD (4.7 +/- 0,8h) and MD (4.1 +/- 1.1h)". F and V are both VERIFIED and stay: the record correctly took the healthy-CONTROL arm of a malabsorption study, "59.4 +/- 6.2% in patients vs 79.5 +/- 8.6% in controls", refined here to 0.795, and its volume is IV-derived at 3.05 L/kg so CLASS 6 IS ACQUITTED and class 8 is excluded outright - "the drug was not concentrated in the red cell". CONFLICTS SURFACED HONESTLY: one study gives 2.9 h and 53% instead, and a third route to F is a derived 1 minus a 20% first-pass. The 5-HT1A emax is corrected separately, and our own fu_note is factually wrong about its own premise. PK: THE STORED ABSORPTION RATE WAS THE SOLVER DEFAULT WEARING A CITATION. A ka of 1.0/h is exactly what resolvePk substitutes when the field is ABSENT, and no source on this record states one. Removing it is NUMERICALLY A NO-OP — the resolver supplies the identical number — so no curve moves; what changes is that the record stops asserting an absorption rate it never measured. This is the same shape already found on a volume of 35 L, which is likewise the default at the seventy-kilogram reference. THE WIDER DEBT IS LEFT ALONE ON PURPOSE: twelve values account for 152 of the 276 authored absorption rates, but the other eleven are NOT the default, so deleting those would move their curves rather than leave them, which is the error this audit spent a batch documenting.
Pharmacokinetics
- Oral — t½ 4.7 h · F 80% · Vd 213 L
Sources: PMID:6487506, PMID:9536453, PMID:639828, PMID:427002